drawer layouts differ between models.
The main-wash compartment is used for detergent in a standard cycle. The pre-wash compartment is only for a cycle that actually includes a pre-wash. Adding detergent to this section during an ordinary cycle may mean the product is flushed away at a stage when you did not intend it to be used. Fabric softener belongs in its marked section, which usually has a maximum fill line.
If the symbols are worn or unclear, check the machine’s manual or the manufacturer’s website using the model number.